Abstractftz is one of the ‘pair rule’ segmentation genes of Drosophila melanogaster, and is an important component of the segmentation process in the fruit fly. We discuss the transcriptional mechanism which causes ftz to be expressed in a seven stripe pattern during embryogenesis.

ExcerptCarl Schmitt (1888–1985) is known as the most consequential German legal and political mind of the twentieth century.1 Many crimes of the Nazi regime found support in his conceptual justifications, and Schmitt is called the “Crown Jurist” of the Third Reich with good reason. Historians, political scientists, and sociologists must grapple with the author in order to understand the course of totalitarianism in modernity. Whether literary historians should do so is far less settled, though he was fascinated by their object (...) of study. His writings on literary topics are said to reveal much about Schmitt’s person, politics, and period, but little about literature itself.2 This explains why his “Don Quijote und das Publikum” (“Don Quixote and the Public”), published in the arts and cultural journal Die Rheinlande in 1912, was almost unknown in literary studies for a century.3 Schmitt’s text on the novel by Miguel de Cervantes has not been reprinted, and until recently it had not been translated from the original German. Size has a role too. At under two thousand words, the text has probably escaped notice due to its small scale.4 Recent English and Italian translations in major humanistic journals may signal the end of its obscurity though.5 “Don Quixote and the Public” is at the door of literary studies. The question now is not whether to respond, but how. (shrink)

This paper suggests an alternative reading of Practice in Christianity to Merold Westphal’s interpretation of the text as defining what he calls “religiousness C.” Attending closely to the rhetorical construction of Practice, and situating it in the context of Kierkegaard’s intensive reading of Luther late in his life, I argue that this text extends the Postscript’s meditation on inwardness and writing to one of the central theological constructs of Lutheranism, the distinction between law and gospel. On my reading, Practice both (...) defends the primacy of faith and grace within Christianity, and refuses their commodification into directly communicable results. At the end of this paper, I consider Kierkegaard’s seeming retraction, in 1855, of two rhetorical features of Practice that my reading emphasizes. Iconclude that this gesture in fact intensifies Kierkegaard’s appropriation of the law/gospel paradigm, and speaks to the impossibility of any direct, comprehensive, and final account of authentic Christian life. (shrink)

Thermodynamics is the foundation of many of the topics of interest in the religion‐science dialogue. Here a nonmathematical outline of the principles of thermodynamics is presented, providing a historical and conceptually understandable development that can serve teachers from disciplines other than physics. The contributions of Gibbs to both classical and rational thermodynamics, emphasizing the importance of the ensemble in statistical mechanics, are discussed. The seminal ideas of Boltzmann on statistical mechanics are contrasted to those of Gibbs in a discussion of (...) the microscopic interpretation of the second law. The role of information theory is discussed, and the modern ideas of Prigogine and nonequilibrium are outlined in some detail with further reference to the second law. Implications for our interaction with God are considered. (shrink)

Abstract.The basic laws of physics for particles and fields can be formulated in terms of variational principles. The initial development of a variational principle had distinct teleological implications. The formulation of physical laws in terms of variational principles is outlined with specific reference to classical and quantum mechanics and field theory. Because of time irreversibility no variational principle exists for thermodynamics. In order to obtain time irreversibility molecular trajectories must be abandoned in the lowest‐level description of complex multicomponent systems. A (...) more open set of possibilities results. I suggest that this may be more consistent with a modern teleology. (shrink)

At least seven orphan members of the nuclear receptor superfamily are transcriptionally regulated by the steroid hormone ecdysone and expressed during the onset of Drosophila metamorphosis. A recent paper provides functions for two of these receptors, E75B and DHR3, through trans‐regulation and heterodimerization(1). DHR3 appears to function as a switch that defines the transition from a late larva to a prepupa, and E75B functions as a timer that modulates this transition. This study provides a biological function for orphan receptor interactions (...) during development. (shrink)

English translations of three major narrative poems and ten shorter texts written in the 14th and 13th centuries B.C.E. in what is now Syria and Lebanon, where they were discovered on tablets in the second quarter of the 20th century. Parallel columns match transliteration of the original cuneiform with line-by-line translation. The texts are supported by introductions, textual (rather than historical or literary) annotations, and a glossary mostly of place and personal names without pronunciation guides. Paper edition (unseen), $14.95. Annotation (...) copyrighted by Book News, Inc., Portland, OR. (shrink)

Ursula Coope's volume sets out to answer the question of why "true freedom" necessitates "freedom from bodies" according to the Neoplatonists. As a result, while the title suggests a work on ethics, the volume handles such questions within a broader metaphysical framework. Coope admirably traces the initially separate treatments of freedom and responsibility in earlier thinkers before examining how they merge into twin aspects of a related discussion. The handling of Plato's concept of freedom in the first chapter outlines a (...) series of relevant issues, rather than evaluating their relative significance, since the primary focus is on the subsequent tradition. The title is somewhat misleading since much of the... (shrink)

The quantum‐measurement problem and the Heisenberg indeterminacy principle are presented in the language of the Dirac formulation of the quantum theory. Particularly the relationship between quantum state prior to measurement and the result of the measurement are discussed. The relation between the indeterminacy principle and the analog between quantum and classical systems is presented, showing that this principle may be discussed independently of the wave‐particle duality. The importance of statistics in the treatment of many body systems is outlined and the (...) approach to investigating God's interaction with human beings is discussed in this context. The treatment is nonmathematical. (shrink)

John Polkinghorne is a significant contributor to the religion and science dialogue, bringing the expertise of a scientist coupled with serious theological study, ordination, and service as a parish priest. He takes both theology and science with utmost seriousness and describes himself as a bottom‐up thinker, confronting the scriptural record as a scientist does data. But he refrains from giving scientific explanations of scripture. Polkinghorne's concern is with hope, and specifically with eschatological hope. The framework for his theological thinking is (...) the Nicene Creed, in which is found the counterintuitive openness common to theoretical physics. He acknowledges the need for thinking beyond the confines of present scientific understanding in proposing active information as a concept for considering the mind. (shrink)

Sixteen years ago, Michael Ashburner and his colleagues proposed a hierarchical model for the genetic control of polytene chromosome puffing by the steroid hormone ecdysone. The recent molecular isolation and characterization of three early ecdysone‐inducible genes has confirmed many aspects of this model — these genes are directly induced by ecdysone, repressed by ecdysone‐induced proteins, and appear to encode DNA binding regulatory proteins. The three early genes are also remarkably similar in structure. They are all unusually long and complex, with (...) multiple transcripts that direct the synthesis of several related proteins from each locus. Proteins encoded by two of the early genes bind to both early and late ecdysone‐induced puffs, implying that they are key regulators in the hierarchy. (shrink)

Programmed cell death is a critical part of normal development, removing obsolete tissues or cells and sculpting body parts to assume their appropriate form and function. Most programmed cell death occurs by apoptosis of individual cells or autophagy of groups of cells. Although these pathways have distinct morphological characteristics, they also have a number of features in common, suggesting some overlap in their regulation. A recent paper by Lee and Baehrecke provides further support for this proposal.(1) These authors present, for (...) the first time, a genetic analysis of autophagy, using the steroid‐triggered metamorphosis of Drosophila as a model system. They demonstrate a remarkable degree of overlap between the control of apoptosis and autophagy as well as a key role for the steroid‐inducible gene E93 in directing the autophagic death response. This paper also shows that E93 can direct cell death independently from the known death‐inducer genes, defining a novel death pathway in Drosophila. BioEssays 23:677–682, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Recently, the outsourcing of Information Technology activities to offshore locations has been gaining significant momentum, with some associated backlash by the workforce in the United States. Based on their 2005 survey [6], Global Insight, a private consulting firm, estimated that U.S. companies will spend about $38.2 billion in offshore IT services by 2010, compared with about $15.2 billion in 2005, primarily because the expected cost savings will grow by $11.7 billion in the same time period. Binder writing in "Foreign Affairs" (...) [2] states that offshoring expenditures will continue to increase dramatically, and the changes the offshoring phenomenon will bring will transform society. This paper focuses on the social impact of offshoring and the effects of the weighing of costs and benefits as a result of offshoring activities. (shrink)

Lloyd (2009) contends that climate models are confirmed by various instances of fit between their output and observational data. The present paper argues that what these instances of fit might confirm are not climate models themselves, but rather hypotheses about the adequacy of climate models for particular purposes. This required shift in thinking—from confirming climate models to confirming their adequacy-for-purpose—may sound trivial, but it is shown to complicate the evaluation of climate models considerably, both in principle and in practice.

This book deals with foundational issues in the theory of the nature of action, the intentionality of action, the compatibility of freedom of action with determinism, and the explantion of action. Ginet's is a volitional view: that every action has as its core a 'simple' mental action. He develops a sophisticated account of the individuation of actions and also propounds a challenging version of the view that freedom of action is incompatible with determinism.

According to one large family of views, scientific explanations explain a phenomenon (such as an event or a regularity) by subsuming it under a general representation, model, prototype, or schema (see Bechtel, W., & Abrahamsen, A. (2005). Explanation: A mechanist alternative. Studies in History and Philosophy of Biological and Biomedical Sciences, 36(2), 421–441; Churchland, P. M. (1989). A neurocomputational perspective: The nature of mind and the structure of science. Cambridge: MIT Press; Darden (2006); Hempel, C. G. (1965). Aspects of scientific (...) explanation. In C. G. Hempel (Ed.), Aspects of scientific explanation (pp. 331–496). New York: Free Press; Kitcher (1989); Machamer, P., Darden, L., & Craver, C. F. (2000). Thinking about mechanisms. Philosophy of Science, 67(1), 1–25). My concern is with the minimal suggestion that an adequate philosophical theory of scientific explanation can limit its attention to the format or structure with which theories are represented. The representational subsumption view is a plausible hypothesis about the psychology of understanding. It is also a plausible claim about how scientists present their knowledge to the world. However, one cannot address the central questions for a philosophical theory of scientific explanation without turning one’s attention from the structure of representations to the basic commitments about the worldly structures that plausibly count as explanatory. A philosophical theory of scientific explanation should achieve two goals. The first is explanatory demarcation. It should show how explanation relates with other scientific achievements, such as control, description, measurement, prediction, and taxonomy. The second is explanatory normativity. It should say when putative explanations succeed and fail. One cannot achieve these goals without undertaking commitments about the kinds of ontic structures that plausibly count as explanatory. Representations convey explanatory information about a phenomenon when and only when they describe the ontic explanations for those phenomena. (shrink)

This article explores some of the roles of computer simulation in measurement. A model-based view of measurement is adopted and three types of measurement—direct, derived, and complex—are distinguished. It is argued that while computer simulations on their own are not measurement processes, in principle they can be embedded in direct, derived, and complex measurement practices in such a way that simulation results constitute measurement outcomes. Atmospheric data assimilation is then considered as a case study. This practice, which involves combining information (...) from conventional observations and simulation-based forecasts, is characterized as a complex measuring practice that is still under development. The case study reveals challenges that are likely to resurface in other measuring practices that embed computer simulation. It is also noted that some practices that embed simulation are difficult to classify; they suggest a fuzzy boundary between measurement and non-measurement. 1 Introduction2 A Contemporary View of Measurement3 Three Types of Measurement4 Can Computer Simulations Measure Real-World Target Systems?5 Case Study: Atmospheric Data Assimilation5.1 Why data assimilation?5.2 A complex measuring practice under development5.3 Epistemic iteration6 The Boundaries of Measurement7 Epistemology, Not Terminology. (shrink)

Some philosophers writing on the possibility of faultless disagreement have argued that the only way to account for the intuition that there could be disagreements which are faultless in every sense is to accept a relativistic semantics. In this article we demonstrate that this view is mistaken by constructing an absolutist semantics for a particular domain – aesthetic discourse – which allows for the possibility of genuinely faultless disagreements. We argue that this position is an improvement over previous absolutist responses (...) to the relativist's challenge and that it presents an independently plausible account of the semantics of aesthetic discourse. (shrink)

The topics of gravitational field energy and energy-momentum conservation in General Relativity theory have been unjustly neglected by philosophers. If the gravitational field in space free of ordinary matter, as represented by the metric g ab itself, can be said to carry genuine energy and momentum, this is a powerful argument for adopting the substantivalist view of spacetime.This paper explores the standard textbook account of gravitational field energy and argues that (a) so-called stress-energy of the gravitational field is well-defined neither (...) locally nor globally; and (b) there is no general principle of energy-momentum conservation to be found in General Relativity. I discuss the nature and justification of the zero-divergence law for ordinary stress-energy, and its possible connection with the failure of General Relativity to realise Mach's principle. (shrink)

This paper considers issues raised by Elizabeth Anderson’s recent critique of the position she terms ‘luck egalitarianism’. It is maintained that luck egalitarianism, once clarified and elaborated in certain regards, remains the strongest egalitarian stance. Anderson’s arguments that luck egalitarians abandon both the negligent and prudent dependent caretakers fails to account for the moderate positions open to luck egalitarians and overemphasizes their commitment to unregulated market choices. The claim that luck egalitarianism insults citizens by redistributing on the grounds of paternalistic (...) beliefs, pity and envy, and by making intrusive and stigmatizing judgments of responsibility, fails accurately to characterize the luck egalitarian’s rationale for redistribution and relies upon luck egalitarians being insensitive to the danger of stigmatization. The luck egalitarian position is reinforced by the fact that Anderson’s favoured conception of equality, ‘democratic equality’, is counterintuitively indifferent to all unchosen inequalities, including intergenerational inequalities, once bare social minima are met. (shrink)

This chapter identifies conditions under which robust predictive modeling results have special epistemic significance—related to truth, confidence, and security—and considers whether those conditions are met in the context of climate modeling today. The findings are disappointing. When today’s climate models agree that an interesting hypothesis about future climate change is true, it cannot be inferred, via the arguments considered here anyway, that the hypothesis is likely to be true, nor that confidence in the hypothesis should be significantly increased, nor that (...) a claim to have evidence for the hypothesis is now more secure. In some other modeling contexts, the prospects for such arguments are brighter. (shrink)

_Slow Cures and Bad Philosophers_ uses insights from the philosophy of Ludwig Wittgenstein to rethink bioethics. Although Wittgenstein produced little formal writing on ethics, this volume shows that, in fact, ethical issues permeate the entirety of his work. The scholars whom Carl Elliott has assembled in this volume pay particular attention to Wittgenstein’s concern with the thick context of moral problems, his suspicion of theory, and his belief in description as the real aim of philosophy. Their aim is not (...) to examine Wittgenstein’s personal moral convictions but rather to explore how a deep engagement with his work can illuminate some of the problems that medicine and biological science present. As Elliott explains in his introduction, Wittgenstein’s philosophy runs against the grain of most contemporary bioethics scholarship, which all too often ignores the context in which moral problems are situated and pays little attention to narrative, ethnography, and clinical case studies in rendering bioethical judgments. Such anonymous, impersonal, rule-writing directives in which health care workers are advised how to behave is what this volume intends to counteract. Instead, contributors stress the value of focusing on the concrete particulars of moral problems and write in the spirit of Wittgenstein’s belief that philosophy should be useful. Specific topics include the concept of “good dying,” the nature of clinical decision making, the treatment of neurologically damaged patients, the moral treatment of animals, and the challenges of moral particularism. Inspired by a philosopher who deplored “professional philosophy,” this work brings some startling insights and clarifications to contemporary ethical problems posed by the realities of modern medicine. _Contributors._ Larry Churchill, David DeGrazia, Cora Diamond, James Edwards, Carl Elliott, Grant Gillett, Paul Johnston, Margaret Olivia Little, James Lindemann Nelson, Knut Erik Tranoy. (shrink)

As social media becomes increasingly popular, human subjects researchers are able to use these platforms to locate, track, and communicate with study participants, thereby increasing participant retention and the generalizability and validity of research. The use of social media; however, raises novel ethical and regulatory issues that have received limited attention in the literature and federal regulations. We review research ethics and regulations and outline the implications for maintaining participant privacy, respecting participant autonomy, and promoting researcher transparency when using social (...) media to locate and track participants. We offer a rubric that can be used in future studies to determine ethical and regulation-consistent use of social media platforms and illustrate the rubric using our study team’s experience with Facebook. We also offer recommendations for both researchers and institutional review boards that emphasize the importance of well-described procedures for social media use as... (shrink)

This article constructively retrieves St. Anselm of Canterbury’s theory of retributive justice and provides a defense of what can be called the retributive model of hell. In the first part of this article, we develop the place of retributive punishment in Anselm’s thinking and discuss how and when retributive punishment is a good thing. In the second part, we apply Anselm’s thinking on retributive justice to the problem of hell and provide a defense of how hell, defined as a state (...) of receiving retributive, damnatory, and irreversible punishment, is good. We then address a series of objections. Despite some criticism that both Anselm and the retributive model of hell receive in the contemporary literature, Anselm’s account of retributive justice can make unique and constructive contributions to the contemporary discussion of hell; by retrieving and applying Anselm’s thought to the problem of hell, we intend to kill two birds with one stone. (shrink)

Social distancing has become the most prominent measure many countries have implemented to combat the spread of COVID-19. The aim of the current study was to explore the potential role of empathy and self-construal styles, as individual personality traits, on self-reported social distancing. Participants completed the Interpersonal Reactivity Index, the Singelis Self-Construal Scale, and were asked to rate their level of social distancing and how much they endorsed social distancing on a five-point Likert-scale. Across a large and diverse sample, results (...) showed that trait-levels of empathic concern and perspective taking positively correlates with social distancing. However, we did not find evidence to suggest that trait-levels of personal distress correlates with social distancing. We interpret these findings as suggesting that empathy, both its altruistic and cognitive dimensions, plays an important role in motivating people to socially distance and should be emphasized during times of crisis. Furthermore, we suggest that emphasizing a person’s self-distress during times of crisis may not be an effective approach in promotion social distancing policies. We also found that both independence and interdependence self-construal styles positively correlates with social distancing. While we expected the latter result, we did not expect the former. This suggests that more work is needed to fully understand how self-construal styles, along with their cultural level analogs, influences social distancing. Overall, these results provide us with novel multi-national data about the role of individual differences on social distancing tendencies specifically, and human behavior during a global health crisis more generally. (shrink)

In this first issue of the new Erkenntnis, it seems fitting to recall at least briefly the character and the main achievements of its distinguished namesake and predecessor. The old Erkenntnis came into existence when Hans Reichenbach and Rudolf Carnap assumed the editorship of the Annalen der Philosophie and gave the journal its new title and its characteristic orientation; the first issue appeared in 1930. The journal was backed by the Gesellschaft f r Empirische Philosophie in Berlin, in which Reichenbach, (...) Walter Dubislav, and Kurt Grelling were the leading figures, and by the Verein Ernst Mach in Vienna, whose philosophical position was strongly influenced by that of the Vienna Circle; a brief account of these groups, and of several kindred schools and trends of scientific and philosophical thinking, was given by Otto Neurath in his 'Historische Anmerkungen' (Vol. 1, pp. 311-314). As Reichenbach noted in his introduction to the first issue, the editors of Erkenntnis were concerned to carry on philosophical inquiry in close consideration of the procedures and results of the various scientific disciplines: analysis of scientific research and its presuppositions was expected to yield insight into the character of all human knowledge, while at the same time, the objectivity and the progressive character of science inspired the convection that philosophy need not remain an array of conflicting 'systems', but could attain to the status of objective knowledge. As a student in Berlin and Vienna during those years, I experienced vividly the exhilarating sense, shared by those close to those two philosophical groups, of being jointly engaged in a novel and challenging intellectual enterprise in which philosophical issues were dealt with 'scientifically' and philosophical claims were amenable to support or criticism by logically rigorous arguments. The 'logical analyses' and 'rational reconstructions' set forth by adherents of this program often made extensive use of the concepts, methods, and symbolic apparatus of contemporary symbolic logic, whose importance for philosophy was the subject of Carnap's article, 'Die Alte und die Neue Logik', which appeared in the first issue.. (shrink)

Written in the late 1950s at the height of popular fascination with UFO's, _Flying Saucers_ is the great psychologist's brilliantly prescient meditation on the phenomenon that gripped the world. A self-confessed sceptic in such matters, Jung was nevertheless intrigued, not so much by their reality or unreality, but by their psychic aspect. He saw flying saucers as a modern myth in the making, to be passed down the generations just as we have received such myths from our ancestors. In this (...) wonderful and enlightening book Jung sees UFO's as 'visionary rumours', the centre of a quasi-religious cult and carriers of our technological and salvationist fantasies. 40 years later, with entire religions based on the writings of science fiction authors, it is remarkable to see just how right he has proved to be. (shrink)

Ronald Dworkin maintains that value is unitary, in the sense that different values do not conflict. This article resists this ‘hedgehog’ view with reference to the values of equality and utility. These appear to yield conflicting prescriptions in cases where one possible distribution gives different individuals the same amount of advantage, and the other contains an unequal distribution of a greater overall amount of advantage. Hedgehogs might respond to such a case in two ways. First, they might claim that equality (...) and utility are not truly in conflict. However, this claim seems implausible on our ordinary concepts of these values, and Dworkin does not provide grounds for revising our concepts. Second, they might deny that one of these values – utility – is a genuine value. However, one of the two aspects of Dworkin’s fundamental principle of equal concern appears to be supportive of utility, and he offers no good arguments for his preferred strategy of accommodating this aspect of equal concern within the value of equality. Furthermore, the alternative ‘fox’ view, which recognizes equality and utility as conflicting values, each accommodating one aspect of equal concern, has the advantage that it stays truer to familiar moral concepts. (shrink)

For Māori, a real opportunity exists to flesh out some terms and concepts that Western thinkers have adopted and that precede disciplines but necessarily inform them. In this article, we are intent on describing one of these precursory phenomena—Foucault’s Gaze—within a framework that accords with a Māori philosophical framework. Our discussion is focused on the potential and limits of colonised thinking, which has huge implications for such disciplines as education, among others. We have placed Foucault’s Gaze alongside a Māori metaphysics (...) and have speculated on the Gaze’s surveillant/expectant strategies with some key Māori primordial phenomena in mind, such as ‘te kore’ and ‘āhua’. We posit the Gaze as an entity and thus aim to render it more relevant to Māori, so that it can be addressed appropriately. We also preface that discussion by theorising on some of the challenges that confront us as Māori authors in even referring counter-colonially to the Gaze. Whilst we do not seek to destabilise the Gaze by positing it as a metaphysically based entity, we do hint at the possibility that critical indigenous philosophy may even for a short time bring the Gaze into focus for Māori. By introducing an awareness of an alternative metaphysics, we may have unsettled the self-certainty of the Gaze. (shrink)

The dissolution of the U.S.S.R. marked also the end of the communist system. However, its replacement by a working democracy is not assured. First a 'civil society', built upon a pluralistic infrastructure, has to be established. This requires the achievement of a 'law-based state', pluralism in the political media, an unshackled media, and freedom of religion. The distinguished experts in these fields brought together in this book question whether such an infrastructure is firm enough as yet to preclude reversion to (...) an authoritarian system. Current events in Russia form an experiment of incalculable importance to the future of the international system - Russian Pluralism-Now Irreversible? offers a lucid, stimulating assessment of the experiment's chances for success. (shrink)